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KMID : 1143120190090040033
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Asia Pacific Allergy
2019 Volume.9 No. 4 p.33 ~ p.33
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The risk of preschool asthma at 2?4 years is not associated with leukocyte telomere length at birth or at 1 year of age
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Suh Dong-In
Kang Mi-Jin
Park Yoon-Mee
Lee Jun-Kyu
Lee So-Yeon
Sheen Youn-Ho
Kim Kyung-Won
Ahn Kang-Mo
Hong Soo-Jong
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Abstract
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Background: Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship.
Objective: We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is associated with increased risk of asthma development during the preschool period.
Methods: We assessed the follow-up clinical data of a subgroup from a birth cohort whose LTLs had been measured from cord-blood and 1-year peripheral-blood samples. We examined whether the LTLs would be associated with asthma development at the age of 2?4 years.
Results: The data of 84 subjects were analyzed. LTLs were measured from the cord-blood and 1-year peripheral blood of 75 and 79 subjects, respectively. Among them, 14 subjects (16.7%) developed bronchial asthma between 2?4 years old. Prenatally stressed subjects had marginally increased odds of developing asthma (p = 0.097). There was no significant difference in the odds of preschool-asthma development between the groups with shorter and longer cord-blood LTLs (odds ratio [OR], 0.651; 95% confidence interval [CI], 0.184?2.306) or in the odds between the groups with shorter and longer 1-year peripheral-blood LTLs (OR, 0.448; 95% CI, 0.135?1.483). Finally, subjects with both higher prenatal stress and shorter LTLs did not have significantly higher odds of preschool-asthma development (for cord-blood: OR, 1.242; 95% CI, 0.353?4.368; for 1-year peripheral-blood: OR, 1.451; 95% CI, 0.428?4.919).
Conclusion: There was no significant association between early life LTLs and higher risk of bronchial-asthma development during the preschool years.
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KEYWORD
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Allergy, Asthma, Bronchial diseases, Child, Preschool, Oxidative stress, Telomere shortening
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